CgA344-364) is a vasoreactive and anti-hypertensive peptide derived from Chromogranin A (CgA). Using the isolated avascular frog heart as a bioassay, in which the interactions
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Corresponding Author: *S. K. Mahata, Department of Medicine, University of California & VA San Diego Healthcare System, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0838 USA. Tel: (858)552-8585, x2637; Fax: (858)642-6425; email: [email protected] or *Bruno Tota, Department of Cell Biology University of Calabria 87030 Arcavacata di Rende (CS) Italy. Phone. +39-0984-492907; Fax: +39-0984492906 ; e-mail: [email protected] Articles in PresS. Am J Physiol Heart Circ Physiol (May 9, 2008). doi:10.1152/ajpheart.00172.2008
منابع مشابه
Catestatin (chromogranin A344-364) is a novel cardiosuppressive agent: inhibition of isoproterenol and endothelin signaling in the frog heart.
The catecholamine release-inhibitory catestatin [Cts; human chromogranin (Cg) A(352-372), bovine CgA(344-364)] is a vasoreactive and anti-hypertensive peptide derived from CgA. Using the isolated avascular frog heart as a bioassay, in which the interactions between the endocardial endothelium and the subjacent myocardium can be studied without the confounding effects of the vascular endothelium...
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Catestatin (CST), the 21-amino acid, cationic and hydrophobic peptide proteolytically derived from the ubiquitous chromogranin A (CgA), is an endogenous inhibitor of catecholamine release, a potent vasodilator in vivo and an anti-hypertensive agent in mammals, including humans. Recently, we discovered that CST also functions as an important negative modulator of heart performance in frog and ra...
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Together with Chromogranin B and Secretogranins, Chromogranin A (CGA) is stored in secretory (chromaffin) granules of the diffuse neuroendocrine system and released with noradrenalin and adrenalin. Co-stored within the granule together with neuropeptideY, cardiac natriuretic peptide hormones, several prohormones and their proteolytic enzymes, CGA is a multifunctional protein and a major marker ...
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تاریخ انتشار 2008